Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat

Figure 4

The effects of inhibition or activation of spinal GABA receptors on mechanical sensitivity following CCD. In sham-operated rats (a), an intrathecal (i.t.) administration of bicuculline (15 nmol) or CGP52432 (15 nmol) produced a decrease in the paw withdrawal thresholds (PWTs) for at least 150 min. On 1 week after CCD (b), an i.t. administration of muscimol (5 nmol) or baclofen (25 nmol) reversed the decreased PWTs for longer than 90 min. On 18 weeks after CCD (c), bicuculline (15 nmol) or CGP52432 (15 nmol) resulted in the decrease of PWTs for at least 150 min. when compared with saline-treated control.

(a)

(b)

(c)