Andrographolide Stimulates Neurogenesis in the Adult Hippocampus

Figure 6

ANDRO stimulates proliferation and the density of immature neurons in the dentate gyrus of APPswe/PSEN1ΔE9. Seven-month-old APPswe/PSEN1ΔE9 mice were injected i.p. with 2 mg kg⁻¹ ANDRO or vehicle as control 3 times a week per 4 weeks. (a) Representative images of double immunostaining for Ki67 and NeuN. The graph shows quantification of the total number of Ki67-positive (Ki67+) cells (yellow arrows) in the SGZ of mice treated with vehicle or ANDRO. Scale bar: 20 μm. (b) Images show representative double immunostaining for DCX and NeuN. Scale bar: 20 μm. Graph differences in the density of immature DCX-positive (DCX+) neurons in control and ANDRO-treated APPswe/PSEN1ΔE9 mice. Bars represent mean ± S.E. ( (a) or (b) mice). , Student’s -test.

(a)

(b)