CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation

Figure 5

Genetic silencing of CRMP2 inhibits the promoting effect of CRMP4 on growth cone development and axonal elongation. (a) Representative images of growth cones with indicated transfections are shown. Scale bar: 10 μm. Relative ratio of the growth cone area was measured and shown in the right panel. Mean ± SEM, ; versus vector control; versus NC. (b) Hippocampal neurons were transfected with the indicated plasmids or siRNA fragments together with GFP. Representative images of GFP staining are shown. Axon length was measured as the mean ± SEM from three independent experiments (). versus vector control; versus NC. Scale bar: 100 μm.

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