P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction

<div>Modulation of inhibitory synaptic transmission by P2Y receptors in the CNS. The cartoon shows an idealized inhibitory (GABAergic) synapse between an inhibitory interneuron and an excitatory principal cell. The effects of P2Y receptors have been described in different brain areas. For more details see text. GABA<sub>A</sub>R, GABA<sub>A</sub> receptor; Glu, glutamate; LTP, long-term potentiation; P2YR, P2Y receptor; P2Y<sub>1</sub>R, P2Y<sub>1</sub> receptor.</div>

Neural Plasticity

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Figure 2: P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction 