Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury

Table 2

The function of miRNAs that might have therapeutic potential for the treatment of SCI.

Cell type	miRNA	Target	Function	Experiment	Reference
Neuron	miR-199a	PTEN	Impeding neurite outgrowth	In vivo	[112]
	miR-124	ROCK1	Promoting neurite outgrowth	In vitro	[98]
	miR-133b	RhoA	Promoting neurite outgrowth	In vitro	[90]
Astrocytes	miR-21	Unidentified	Attenuating the astrocytes hypertrophic response to SCI	In vivo	[66]
	miR-145	BMP	Reducing astrocytic cell density at the lesion border of the injured spinal cord	In vivo	[39]
	miR-146	GFAP, c-Myc	Regulating inflammation response	In vitro	[70, 71]
	miR-181	SOD2	Reducing astrocyte death in vitro and infarct volume after stroke in vivo	In vivo and in vitro	[31, 60]
	miR-125b	CDKN2A	Promoting astrogliosis and defects in the cell cycle	In vivo	[72]
	miR-486	NeuroD6	Neuroprotection	In vivo	[115]
Oligodendrocyte	Let-7	Sox4, UHRF1b-p1	Promoting myelination	In vitro	[73]
	miR-9	PMP22	Promoting OLs differentiated	In vitro	[116]
	miR-23	LaminB1	Promoting oligodendrocyte development and myelination	In vitro	[78, 79]
	miR-138	Sox4	Promoting OL differentiation	In vitro	[73]
	miR-219	PDGFR-α, Sox6, FoxJ3, ZFP238	Promoting OPC proliferation	In vivo	[73, 75]
	miR-146	Unidentified	Promoting oligodendrogenesis	In vivo	[117]