Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer’s Diseases

Table 1

Major references studying TRPM2 channel in plasticity and AD.

Experimental approach	Effects	Reference
TRPM2 KO hippocampal slice	Deficit in LTD, GSK3β inactivation	[39]
TRPM2 KO glia and neuron culture	Glutathione homeostasis loss, inflammation	[21, 48]
TRPM2 KO animal stroke	Neuroprotection, GSK3β inhibition	[54]
Expression of TRPM2 in striatal culture, Aβ/oxidative stress	Cell death	[52]
Human microglia culture, rat brain ischemia, inflammation/oxidative stress/electrophysiology	TRPM2 activated in microglia by ADPR	[24]
TRPM2 KO, ROS and inflammation in whole animal	Negative feedback	[19]
Neuropathic and inflammatory pain in TRPM2 KO animal	Inhibition of microglia and pain in KO mice	[17, 22]
Expression of TRPM2 in human glioblastoma, oxidative stress	Promoting cell death	[55]
Electrophysiology in microglia, ADPR/H2O2	Induction of Ca^2+ influx and TRPM2 current	[26, 56]
Diabetic rat, brain and DRG	TRPM2 activity and oxidative stress enhanced	[50]
Pharmacological gene deletion of TRPM2 in microglia	TRPM2 mediates inflammation through p38MAPK/JNK	[28]
TRPM2/APP/PS1 KO mice	Absent microglia activation and memory impairment	[20]