TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch

Figure 4

The effects of G protein, PLC, and TRP inhibitor on the immepip-induced increase in of DRG neurons. (a, c, and e) G protein inhibitor NEM (), PLC inhibitor U73122 (), and TRP channels antagonist ruthenium red () blocked the immepip-induced increase in , but TRPA1 antagonist HC-030031 () could not block the immepip-induced increase in (g). (b, d, f, and h) Mean changes () (340/380) of the responsive neurons. .

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