Pairing Cholinergic Enhancement with Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex

Figure 5

Changes in tuning bandwidth subsequent to training in the different experimental groups. ((a)-(b)) Average BW20 for all neurons recorded in young and older untrained (UT), trained with saline (TS), and trained with rivastigmine (TR) groups and separated by CF. Representative receptive fields of A1 neurons in the same experimental groups. The black arrows point to the lack of change in BW20 in the O-TS group compared to all other groups. (c) Representative tuning curves from each group for neurons with a CF of the nontarget tone (10 kHz) that illustrate the narrowing of the bandwidth in all groups except the O-TS group (Y-UT: , recorded neurons = 189; Y-TS: , recorded neurons = 132; Y-TR: , recorded neurons = 157; O-UT: , recorded neurons = 201; O-TS: , recorded neurons = 138; O-TR: , recorded neurons = 117). Values shown are mean ± SE. : -test.

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