Bilateral Neuropathy of Primary Sensory Neurons by the Chronic Compression of Multiple Unilateral DRGs

Figure 3

Thermal hyperalgesia and cold allodynic behaviors in the mCCD rat. (a) The time course of ipsilateral and contralateral hind paw withdrawal latencies to radiant thermal stimulation in mCCD () and control rats (). Following the chronic compression of multiple DRGs, ipsilateral and contralateral hind paw withdrawal latencies were transiently decreased from the 1st postoperative day to postoperative day 21 compared to those of control groups (RM ANOVA, ipsilateral side: ; contralateral side: ). After 21 days, hind paw withdrawal latencies recovered to the baseline preoperative levels. (b) The time course of ipsilateral and contralateral forepaw withdrawal latencies to radiant thermal stimulation in mCCD () and control rats (). No significant changes in either ipsilateral or contralateral forepaw withdrawal latencies in the mCCD rat (RM ANOVA, ). (c) Response scores of the ipsilateral and contralateral hind paws to acetone in control () and mCCD () rats. Both ipsilateral and contralateral response scores to acetone increased after the chronic compression of multiple DRGs compared with the control group (one-way ANOVA followed by Bonferroni test, ipsilateral: ; contralateral: ). (d) Response frequencies of the ipsilateral and contralateral hind paws to acetone in control and mCCD rats. Cold allodynic response frequencies of both ipsilateral and contralateral hind paws were significantly increased in chronically compressed rats compared to that of the control group (one-way ANOVA followed by Bonferroni test, ipsilateral: ; contralateral: ).

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