Selective Requirement for Maintenance of Synaptic Contacts onto Motoneurons by Target-Derived trkB Receptors

Figure 4

(a) The mean percent coverage (±SEM) by contacts immunoreactive to VGLUT1, VGLUT2, GAD67, or glycine in male and female tamoxifen treated SLICK:: mice. These values were determined for each synapse-associated protein by averaging data from individual mice in the different groups. The significance of differences between groups was then evaluated with ANOVA. The estimated percent coverage by contacts containing glycine equals the percent coverage by VGAT+ contacts minus percent coverage by GAD67. WT refers to wildtype motoneurons without YFP that still retain trkB receptors. KO refers to knockout motoneurons labeled with YFP that do not have trkB receptors. versus WT and versus female. (b) The same data are expressed as mean (±95% confidence limits) percent differences between WT cells and KO cells.

(a)

(b)