Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals
Table 2
MicroRNAs CpG sites differentially methylated in Alzheimer’s disease.
CpG probe ID
Chr: Start site
Associated gene
UCSC_RefGene_Group
Relation_to_CpG_Island
Enhancer
Control
AD
Delta beta
value
cg22806002
11: 111383083
BTG4; MIR34C; MIR34B
TSS200; TSS1500; TSS1500
N_Shore
—
0.314 ± 0.005
0.358 ± 0.008
0.044 (4.4%)
0.0015
cg13149127
1: 156390835
C1orf61; MIR9-1
5′UTR; TSS1500
Island
TRUE
0.045 ± 0.001
0.055 ± 0.002
0.010 (1%)
0.0015
cg09994773
1: 9212514
MIR34A
TSS1500
“open sea”
—
0.826 ± 0.008
0.867 ± 0.011
0.041 (4.1%)
0.0057
cg16865908
11: 121970496
LOC399959; MIR125B1
Body; Body
“open sea”
TRUE
0.068 ± 0.007
0.109 ± 0.015
0.040 (4.0%)
0.0101
cg25851152
10: 10419537
MIR146B
TSS1500
S_Shelf
TRUE
0.072 ± 0.002
0.084 ± 0.002
0.011 (1.1%)
0.0101
cg09148270
11: 111384223
BTG4; C11orf88; MIR34C
TSS1500; TSS1500; Body
N_Shore
—
0.315 ± 0.010
0.372 ± 0.018
0.056 (5.6%)
0.0172
cg14278808
8: 9761141
LOC157627; MIR124-1
TSS1500; TSS200
Island
—
0.042 ± 0.002
0.051 ± 0.002
0.009 (0.9%)
0.0220
cg10822545
19: 13985513
MIR181D; MIR181C
TSS200; Body
S_Shore
—
0.833 ± 0.009
0.864 ± 0.007
0.031 (3.1%)
0.0220
cg02315626
17: 27188560
MIR451; MIR144
TSS200; Body
“open sea”
—
0.802 ± 0.011
0.841 ± 0.011
0.038 (3.8%)
0.0220
cg12530503
15: 89911148
MIR9-3
TSS200
Island
TRUE
0.129 ± 0.005
0.153 ± 0.007
0.024 (2.4%)
0.0349
AD = Alzheimer’s disease; beta values are presented as means ± SEM; delta beta is the average of DNA methylation difference between the two compared groups; Mann-Whitney test, values refer to the statistical analysis of the means of methylation levels from the two compared groups.
