Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

Table 1

Proteins involve in location-dependent NMDAR signaling activation.

Protein	Location of stimulated NMDA receptor	NMDA receptor activation induces ↑ or ↓	Closest partners upstream	Reference
CREB	Syn	↑	CBP phosphorylation by CaMKIV	[42, 43]
	Extrasyn	↓	CREB dephosphorylation by Jacob	[39]
ERK 1/2 (MEK phosphorylation)	Syn	↑	Ras-GTP	[32, 44]
	Extra	↓	Ras-GDP by SynGAP
Ras	Syn	↑	Increase in Ca^2+ Ras-GTP	[32, 44]
	Extrasynaptic	↓	Less Ca^2+; Ras-GDP
FOXO1/FOXO3 (transcription factor, apoptosis inducer)	Syn	↓	FOXO1/3 phosphorylation by akt inducing nuclear export	[35]
	Extrasynaptic	↑	FOXO3a nuclear translocation	[45]
Calpain	Extrasynaptic	↑	Calpain Ca^2+ activated	[46]
STEP	Extrasynaptic	↑	STEP cleaved by calpain	[36]
NCX3	Extrasynaptic	↑	NCX3 cleaved by calpain	[21]
Akt/PI3K	Syn	↑	Akt/PI3K activated through IRS-1	[35, 47, 48]
SynGap	Syn	↑	Activated by CamKII	[49]
CaMKII	Syn	↑	Increase in Ca^2+	[50]