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Neural Plasticity
Volume 2016, Article ID 2754078, 12 pages
Review Article

Hypothalamic AMPK as a Regulator of Energy Homeostasis

Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea

Received 22 April 2016; Accepted 10 July 2016

Academic Editor: Edgar Soria-Gomez

Copyright © 2016 My Khanh Q. Huynh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration.