Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice

Table 1

Summary of experimental results.

	Surrogate	Pup survival	Open field		Forced swim test
		%	Time in center (s)	Beam breaks	Latency to immobility (s)	Total time immobile (s)
Dams
Wild type		92.0 ± 1.0			70.7 ± 6.2	148.3 ± 26.7
Wild type CUS		56.2 ± 0.9			49.5 ± 8.2	245.6 ± 3.3
		65.5 ± 0.9			47.7 ± 2.2	205.5 ± 9.8
CUS		41.7 ± 1.1			55.8 ± 5.2	222.8 ± 8.1
Wild type sham		88.9 ± 2.7
Wild type CORT		20.5 ± 4.4
vehicle		51.9 ± 6.2
Antalarmin		75.0 ± 5.1
Offspring (P21)
Cross-fostered wild type	WT surrogate		82.9 ± 12.6	324.1 ± 29.1	53.6 ± 2.7	107.1 ± 13.7
Cross-fostered mice	WT surrogate		78.6 ± 10.6	331.5 ± 32.4	58.5 ± 6.0	152.9 ± 15.5
Cross-fostered wild type	surrogate		43.3 ± 4.3	250.5 ± 22.8	39.9 ± 5.3	181.4 ± 12.3
Cross-fostered mice	surrogate		40.7 ± 4.2	360.4 ± 24.4	40.9 ± 1.4	208.4 ± 5.0
Wild type sham			65.0 ± 11.2	338.7 ± 20.4	53.0 ± 7.5	124.5 ± 38.2
Wild type CORT			37.0 ± 4.0	546.9 ± 18.1	41.5 ± 4.5	204.4 ± 11.1
vehicle			45.1 ± 7.1	560.3 ± 43.9	49.1 ± 4.1	201.0 ± 3.3
Antalarmin			96.7 ± 12.8	567.0 ± 65.4	71.0 ± 9.3	100.0 ± 23.1

Significance < 0.05 compared to control, sham, or vehicle.
Significance < 0.05 compared to wild type, sham, or vehicle.