Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice

Figure 7

Reactive astrogliosis in the DCN of pcd mouse brain. (a) DCN of wt mouse brain is characterized by the virtual absence of reactive astrocytes. In pcd, the degeneration process is accompanied by a strong astrocytic activation; the DCN seem to be filled with astrocytes. Scale bar: overview 100 μm, detail 20 μm. (b) Western blot analyses confirm the immunocytochemical data. In pcd tissue, the GFAP protein level is more than 2-fold increased (). Data are given as mean ± SEM.

(a)

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