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Neural Plasticity
Volume 2016, Article ID 3131586, 9 pages
http://dx.doi.org/10.1155/2016/3131586
Research Article

Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

1Beijing University of Chinese Medicine, Beijing 100029, China
2Community Health Service Center of Dongcheng District, Beijing 100010, China
3Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China

Received 22 May 2016; Revised 17 September 2016; Accepted 20 October 2016

Academic Editor: Jian Kong

Copyright © 2016 Jing Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer’s disease. Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer’s disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group). After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA), electroacupuncture (EA), Alzheimer’s disease (AD), and normal (N) groups were assessed. Results. The Morris water maze test, micro-PET, and immunohistochemistry revealed that MEA and EA therapies could improve spatial learning and memory ability, glucose metabolism level in the brain, and Aβ amyloid content in the frontal lobe, compared with the AD group (). Moreover, MEA therapy performed better than EA treatment in decreasing amyloid-beta levels in the frontal lobe of mice with AD. Conclusion. MEA therapy may be superior to EA in treating Alzheimer’s disease as demonstrated in SAMP8 mice.