(a)
(b)
(c)
(d)
Figure 4: The effect of WN rearing on paired-pulse responses before (a, b, c) and after (d) LTP induction. (a) There was no significant effect of rearing condition on paired-pulse responses before LTP induction. As groups, both WN and control rats showed little evidence of PPD or PPF. ANOVA results for (a): effect of ISI, F(2.43, 38.88) = 1.78, ; effect of condition, F(1, 16) = 0.04, ; effect of ISI by condition interaction, F(2.43, 38.88) = 1.29, . (b) However, detailed analyses of responses in individual rats revealed that the majority (, control depression) of control rats exhibited PPD, with the remaining rats (, control facilitation) showing substantial PPF, which largely cancelled out the depression seen in the majority of control rats. (c) Similarly, most WN rats (, WN depression) showed clear PPD, and only a minority (, WN facilitation) exhibited PPF (note that panel (a) depicts the group means of data plotted in (b) and (c)). (d) Following LTP induction, both groups exhibited clear PPD. Further, WN-reared rats showed greater levels of PPD than those seen in control animals. ANOVA results for (b): effect of ISI, F(3.05, 48.84) = 10.57, ; effect of condition, F(1, 16) = 6.21, ; effect of ISI by condition interaction, F(3.05, 48.84) = 2.13, .