Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease

Figure 7

Developmental changes in the amplitude and frequency of spontaneous excitatory postsynaptic currents (EPSCs; downward deflections) in hypoglossal motoneurons recorded from the C57/Bl6 WT mice (a), compared to the mice overexpressing the mutated human gene (b) at P0, P15, and P30. The amplitude of EPSCs increased by ~3-fold, while the frequency of EPSCs reduced by ~50% with postnatal maturation (from P0 to P30) in WT mice. In the mutated mice the frequency of EPSCs was increased, without a clear change in EPSC amplitude, compared to age-matched WT littermates. Scale bars = 100 pA, 0.1 s.

(a)

(b)