Increases in Retrograde Injury Signaling Complex-Related Transcripts in Central Axons following Injury

Figure 7

Schematic representation of biphasic axonal response to injury. Upon injury, a fast signal and slower RIS complex transported signal differentially regulate the levels of several transcripts. Changes in axonal protein levels occur over period of 6 hrs, suggesting the dynamic formation of RIS complexes. We posit that the transported RIS complex, via importin -mediated nuclear import, triggers the delayed/second wave of transcriptional changes in the axon.