The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

Figure 4

Schematic representation of Sema3A protein localization in PNNs. Hyaluronan molecules attached to the neuron cell membrane contain link proteins that carry the CS chain bearing CS core proteins. Tn-R act as a cross-linking protein between several CS core proteins present on different hyaluronan molecules. Both Sema3A and OTX2 preferentially bind to the CS-E chains attached to the CS core proteins. After binding to the PNN via CS-E, OTX2 can translocate into the neuron [53, 54], whereas Sema3A appears to reside in the PNN using CS-E as “an anchor.”