The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

Figure 5

Exposure to enriched environment induces a reduction of Sema3A in the cerebellar nuclei of the adult mouse. (a)–(b′) show Sema3A immunostaining (red) around projection neurons of the cerebellar nuclei (stained by SMI32, green) of control mice (a, a′) and mice exposed to enriched environment (b, b′). A clear reduction of Sema3A levels is observed in enriched animals. EE: enriched environment. Scale bar: 50 µm.