The Gate Theory of Pain Revisited: Modeling Different Pain Conditions with a Parsimonious Neurocomputational Model

Figure 12

Synaptic weights and firing threshold values when the gate circuit arrives to stability for the different cases previously explained. When placing the different type of inputs in the gate circuit, neuron 2 response is according to the type of response expected in each case. In the case of graph (b), we considered the parameters of gate circuit that only produces phantom pain when no inputs at all enter the gate (see Figure 7(c)).

(a) Gate standard operation

(b) Phantom limb operation

(c) Demyelinating syndrome operation

(d) Breakthrough pain operation

(e) Wind-down pain

(f) Wind-up pain