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Neural Plasticity
Volume 2016 (2016), Article ID 4195391, 8 pages
http://dx.doi.org/10.1155/2016/4195391
Research Article

Plastic Change in the Auditory Minimum Threshold Induced by Intercollicular Effects in Mice

1School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China
2School of Sport, Hubei University, Wuhan 430062, China
3Key Laboratory of Adolescent Cyberpsychology and Behavior, CCNU, Ministry of Education, Wuhan 430079, China
4School of Psychology, Central China Normal University, Wuhan 430079, China

Received 20 August 2015; Revised 9 November 2015; Accepted 19 November 2015

Academic Editor: Etienne de Villers-Sidani

Copyright © 2016 Hui-Xian Mei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the auditory pathway, the commissure of the inferior colliculus (IC) interconnects the two ICs on both sides of the dorsal midbrain. This interconnection could mediate an interaction between the two ICs during sound signal processing. The intercollicular effects evoked by focal electric stimulation for 30 min could inhibit or facilitate auditory responses and induce plastic changes in the response minimum threshold (MT) of IC neurons. Changes in MT are dependent on the best frequency (BF) and MT difference. The MT shift is larger in IC neurons with BF differences ≤2 kHz than in those with BF differences >2 kHz. Moreover, MTs that shift toward electrically stimulated IC neurons increase with the increasing MT difference between the two ICs. The shift in MT lasts for a certain period of time and then returns to previous levels within ~150 min. The collicular interactions are either reciprocal or unilateral under alternate stimulating and recording conditions in both ICs. Our results suggest that intercollicular effects may be involved in the acoustic experience-dependent plasticity of the MT of IC neurons.