Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons

Figure 4

Molecular networks induced by Wnt3a treatment. Gene composition (nodes) and interactions (edges) are shown for modules M1 (upper right, green background), M2 (middle bottom, light blue background), and M3 (upper right, orange background). Node color represents the observed fold change (FC) upon Wnt3a treatment in a gradient from green (downregulation) to red (upregulation) values (i.e., green, FC < 1; red, FC > 1; white, FC = 1). Similarly, node size is proportional to the    value assigned to the gene behavior. For each module the main GO category associated is shown: M1 = glycerolipid metabolism process (GO:0046486), M2 = learning and memory (GO:0007611), and M3 = neurotransmitter secretion (GO:0007269). Module structure: M1 is composed of 44 genes with 132 interactions; M1 is composed of 25 genes with 32 interactions; and M1 is composed of 30 genes with 62 interactions (see also Supplementary Table ).