Research Article
Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons
Table 3
Top 3 GO categories overrepresented in Wnt3a-induced M1, M2, and M3 subnetworks.
| | Module | Category | GO ID | GO Name | GIP | GIS | -adjusted (BH) |
| | M1 | BP | GO:0046486 | Glycerolipid metabolic process | 193 | 18 | 4.5 × 10−19 | | GO:0006644 | Phospholipid metabolic process | 166 | 17 | 1.1 × 10−18 | | GO:0006650 | Glycerophospholipid metabolic process | 134 | 16 | 1.2 × 10−18 | | MF | GO:0016298 | Lipase activity | 59 | 8 | 5.2 × 10−09 | | GO:0016788 | Hydrolase activity, acting on ester bonds | 430 | 14 | 1.2 × 10−08 | | GO:0004620 | Phospholipase activity | 47 | 7 | 1.7 × 10−08 |
| M2
| BP | GO:0007611 | Learning or memory | 181 | 7 | 4.0 × 10−05 | | GO:0050890 | Cognition | 200 | 7 | 4.4 × 10−05 | | CC | GO:0043256 | Laminin complex | 8 | 4 | 2.0 × 10−07 | | GO:0005610 | Laminin-5 complex | 4 | 3 | 2.9 × 10−06 | | GO:0005605 | Basal lamina | 18 | 4 | 2.9 × 10−06 | | MF | GO:0050839 | Cell adhesion molecule binding | 131 | 7 | 1.1 × 10−06 | | GO:0001948 | Glycoprotein binding | 74 | 5 | 1.7 × 10−05 | | GO:0005178 | Integrin binding | 76 | 5 | 1.7 × 10−05 |
| M3
| BP | GO:0007269 | Neurotransmitter secretion | 82 | 10 | 5.3 × 10−12 | | GO:0006887 | Exocytosis | 176 | 12 | 5.3 × 10−12 | | GO:0016079 | Synaptic vesicle exocytosis | 37 | 8 | 1.2 × 10−11 | | CC | GO:0044456 | Synapse part | 373 | 14 | 2.6 × 10−11 | | GO:0043679 | Axon terminus | 131 | 10 | 7.7 × 10−11 | | GO:0044306 | Neuron projection terminus | 139 | 10 | 9.4 × 10−11 | | MF | GO:0017075 | Syntaxin-1 binding | 16 | 7 | 1.2 × 10−12 | | GO:0000149 | SNARE binding | 69 | 8 | 8.0 × 10−10 | | GO:0019905 | Syntaxin binding | 46 | 7 | 1.7 × 10−09 |
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BP: biological processes; CC: cellular components; MF: molecular function; GO ID: gene ontology term ID; GIP: genes in population; GIS: genes in study; BH: Benjamini-Hochberg correction multiple testing correction.
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