Plasticity in the Neonatal Brain following Hypoxic-Ischaemic Injury
Table 1
Cell death phenotypes.
ā
Cytoplasm
Cell membrane
Nucleus
Apoptosis
(i) Condensation (ii) Shrinkage (iii) Undamaged mitochondria, but might also appear swollen
Undamaged
(i) Large chromatin clusters (ii) Undamaged nuclear membrane
Necrosis
Totally disrupted organelles
(i) Rupture (ii) Swelling
(i) Undamaged nuclear membrane (ii) Widely scattered very small chromatin clusters
Apoptosis-necrosis continuum
(i) Varying degrees of condensation (ii) Rarefaction with varying preservation of organelles (iii) Undamaged mitochondria (iv) Occasional autophagocytic inclusions
Undamaged
(i) Incomplete packaging of nuclear chromatin into small and more numerous clusters (ii) Various degrees of membrane preservation