Plasticity in the Neonatal Brain following Hypoxic-Ischaemic Injury

Table 1

Cell death phenotypes.

	Cytoplasm	Cell membrane	Nucleus
Apoptosis	(i) Condensation; (ii) Shrinkage; (iii) Undamaged mitochondria, but might also appear swollen	Undamaged	(i) Large chromatin clusters; (ii) Undamaged nuclear membrane
Necrosis	Totally disrupted organelles	(i) Rupture; (ii) Swelling	(i) Undamaged nuclear membrane; (ii) Widely scattered very small chromatin clusters
Apoptosis-necrosis continuum	(i) Varying degrees of condensation; (ii) Rarefaction with varying preservation of organelles; (iii) Undamaged mitochondria; (iv) Occasional autophagocytic inclusions	Undamaged	(i) Incomplete packaging of nuclear chromatin into small and more numerous clusters; (ii) Various degrees of membrane preservation