The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders

<div>Function of neurofibromin in neurons. (a) Neurofibromin-interacting proteins. The Jn and Pn fragments interact with syndecan-2. The leucine-rich domain (LRD) binds VCP. The GAP-related domain (GRD) downregulates the Ras pathway. Both GRD and the C-terminal half of neurofibromin are involved in adenylate cyclase activity regulation. CTD, C-terminal region. (b) Neurofibromin controls dendritic filopodia and spine formation through the PKA-Ena/VASP and VCP pathways, respectively.</div>

Neural Plasticity

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Figure 2

Figure 2: The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders 