The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders

<div>CTTNBP2 and neuronal differentiation. (a) Schematic domain structure and CTTNBP2-S-interacting proteins. CC, coiled-coil domain; Mid, middle region; P-rich, proline-rich domain. (b) The function of CTTNBP2-S in neuronal morphogenesis. CTTNBP2-S controls microtubule stability in the dendritic shafts and cortactin mobility in dendritic spines. Upon CTTNBP2 knockdown during dendritic extension, dendritic complexity decreases. During synaptogenesis, CTTNBP2-S helps maintain cortactin in dendritic spines and promotes dendritic spine formation and maintenance.</div>

Neural Plasticity

fig4

Figure 4

Figure 4: The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders 