Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

<div>Flow chart of the PKA inhibitor intervention and PWTs detection in different time points. Before the establishment of pain memory model, intra-ACC cannulation was implanted. H89 microinjection was administered at 5 h and 1–5 d continually. The PWTs at days −1, 0, and 5 in the first injection time and days 13, 14, and 18 in the second injection time were recorded to evaluate pain.</div>

Neural Plasticity

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Figure 2

Figure 2: Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model 

Figure 2 | Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model 