Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

Figure 4

The effects of the PKA inhibitor of pain memory model. The rats were divided into the model + vehicle and the model + H89 groups and the mechanical allodynia was examined (). (a) In the left hind paw (first injected), the PKA inhibitor intervention significantly increased the PWTs from acute inflammatory pain. (b) In the right hind paw (first noninjected), the PWTs of the two groups were not significantly different. (c) In the left hind paw (second noninjected), PKA inhibitor intervention significantly increased the PWTs from pain memory. (b) In the right hind paw (second injected), PKA inhibitor intervention significantly increased the PWTs compared with the model + vehicle group. Error bars indicated SEM. and , versus the model + vehicle group; and , versus baseline.

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