Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

Figure 5

EA inhibited the activation of cAMP in the ACC of pain memory model rats. The right ACC tissues from the control, model, indo, EA, and sham EA groups were prepared and labeled with immunofluorescence (, five slides for each rat). (a) Views of cAMP-positive cells (scale bar, 50 μm). The yellow line indicates the field in which the positive cells were counted. (b) Quantification of cAMP-positive cells showed that EA treatment at the first injection time point significantly reduced the activation of cAMP. Error bars indicated SEM. , versus the control group; , versus the model group; , versus the indo group; , versus the sham EA group.

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