Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1^−/− Mouse

Figure 3

Adult mice emotionality measure in the plus maze apparatus: (a) Time Open + Time Closed, (b) number of entries in the open arms, and (c) percentage of time spent in the open arms. Data are presented as mean (+SEM). : 11–20 per group. µ-KO-L: Oprm1^−/− pups reared by their mother [9 males + 9 females]; µ-KO-L+L: Oprm1^−/− pups reared by their mother plus a second lactating female [6 males + 5 females]; WT-L: Oprm1^+/+ pups reared by their mother [8 males + 12 females]; WT-L+L: Oprm1^+/+ pups reared by their mother plus a second lactating female [11 males + 6 females].

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