Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1^−/− Mouse

Figure 5

Mean (+SEM) percentage of time spent by adult females (a) and males (b) close to a same sex partner of the other homozygous line in a modified version of the Approach-Avoidance Test, where a µ-KO and a WT partner mouse were simultaneously presented to the experimental subject. The dotted line represents chance level (50%). : 12–16 per group. µ-KO-L: Oprm1^−/− pups reared by their mother [16 males + 16 females]; µ-KO-L+L: Oprm1^−/− pups reared by their mother plus a second lactating female [15 males + 15 females]; WT-L: Oprm1^+/+ pups reared by their mother [16 males + 13 females]; WT-L+L: Oprm1^+/+ pups reared by their mother plus a second lactating female [15 males + 12 females]. Difference due to genotype ^⁎.

(a)

(b)