Research Article

Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse

Table 1

Mean (±SEM) body weight (gr.) of mice (males and females) belonging to the four experimental groups.

Experimental groupsOprm1Oprm1ANOVA
LL+LLL+L G RC S

Day 8
 Males4.68 ± 0.15 5.99 ± 0.23 4.60 ± 0.24 6.49 ± 0.10 0.78152.020.14
 Females4.68 ± 0.20 6.31 ± 0.17 4.65 ± 0.17 6.40 ± 0.16

ANOVA
G E S

Days 28–30
 Males16.32 ± 0.48 14.08 ± 0.51 14.86 ± 0.79 15.03 ± 0.89 1.691.410.21
 Females15.64 ± 0.44 15.06 ± 0.56 14.17 ± 0.29 14.54 ± 0.66

ANOVA
G E S

Days 75–80
 Males27.17 ± 0.59 28.06 ± 0.41 25.75 ± 0.87 26.68 ± 0.54 0.680.5390.42
 Females21.36 ± 0.31 21.75 ± 0.30 22.39 ± 0.82 21.74 ± 0.53

G: genotype; RC: rearing condition; S: sex. , .
Sample sizes are reported in brackets.