Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory

Figure 7

Excitatory synaptic transmission on barrel cortical GABAergic neurons increases after pairing WS and OS. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded on the GFP-labeled GABAergic neurons in cortical slices under voltage-clamp (holding potential at −65 mV) in presence of 10 μM bicuculline. (a) shows sEPSCs recorded on the neurons from controls (dark-blue in left panel) and CR-formation (dark-red in right). The bottom traces are the expanded waveforms selected from top traces. Calibration bars are 30 pA, 1 second (top) and 90 ms (bottom). (b) shows cumulative probability versus sEPSC amplitudes from control (dark-blue symbols, ) and CR-formation (dark-red, ). (c) shows cumulative probability versus inter-sEPSC intervals from controls (dark-blue symbols, ) and CR-formation (dark-red symbols, ).

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