Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory

Figure 8

The ability to encode spikes in barrel cortical GABAergic neurons decreases after pairing WS and OS. Spikes were induced by depolarization pulses under voltage-clamp recording on the GABAergic neurons in cortical slices. (a) illustrates depolarization-induced spikes on the neurons from controls (dark-blue trace) and CR-formation (dark-red). (b) shows interspike intervals for spikes 1~2 to spikes 4~5 from controls (dark-blue symbols, ) and CR-formation (dark-red symbols, ). (c) illustrates spikes per second versus normalized stimuli (input-output) from control (dark-blue symbol, ) and CR-formation (dark-red, ). (d) shows the measurement of spike refractory periods on the neurons from control (dark-blue trace) and CR-formation (dark-red). (e) shows refractory periods versus spikes 1 to 4 from controls (dark-blue symbols, ) and CR-formation mice (dark-red symbols, ). (f) illustrates threshold potentials versus spikes 1 to 5 from controls (dark-blue symbols, ) and CR-formation (dark-red symbols, ).

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