Review Article

Regeneration of Zebrafish CNS: Adult Neurogenesis

Figure 6

Expression and regulation of transcription factors involved in neuronal specification. (a) Dorsoventral patterning in the vertebrate neural tube [117]. (b) Dorsoventral patterning in the zebrafish neural tube [114]. (c) Heat map represents differential expression of transcription factors related to dorsoventral repatterning of cord in regenerating adult zebrafish spinal cord [23]. (d) Based on microarray data and expression profiling, predicted model of dorsoventral patterning in the adult regenerating zebrafish spinal cord. (e) A transverse section of 15 DPI adult spinal cord immunostained with HuC/D antibody showing regenerated neurons with characteristic dorsoventral localization (white arrowheads and yellow arrowheads indicating dorsal and ventral neurons, resp.). RP: roof plate; FP: floor plate; NC: notochord; DP: dorsal progenitor; VP: ventral progenitor; VC: vertebral column. Scale bar = 10 μm (e).