Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome

Figure 2

The ENU706 mice possessed moderate hearing loss. (a) A representative case showed the click ABR test in control and ENU706 mice. A control mouse possessed a hearing threshold as low as 20 dB SPL. An ENU706 mouse had 50 dB SPL hearing threshold at the left ear and 60 dB SPL hearing threshold at the right ear. (b) The onset of ABR responses was 0.36 milliseconds later in mutant than that in control mouse. (c) The duration between peaks I and II was not altered obviously in mutant compared to the control. The traces analyzed in (b) and (c) were from the same recordings shown in (a). In (a), (b), and (c), control was shown in black and ENU706 in red. In difference with the control (d), the heterozygous ENU706 mice with elevated ABR responses were found to have otitis media (e).

(a)

(b)

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(e)