Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease

Figure 4

Effects of DSP-4 or 5,7-DHT injection alone on thermal and mechanical sensitivity in rats. (a) Compared to the sham group, paw thermal withdrawal threshold was decreased on the 4th week after bilateral ICV injection of DSP-4 (100 μg/4 μL in each side), but not 5,7-DHT (100 μg/4 μL in each side). ((b)–(d)) Mechanical hypersensitivity was significantly induced from the 2nd week of the end of testing after ICV injection DSP-4, but not 5,7-DHT (, , and compared to the sham group, = 6-7 for each group).

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