Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease

Figure 7

Effects of duloxetine and sertraline on thermal and mechanical hypersensitivity in 6-OHDA-lesioned rats. Rats were i.p. injected with 10 mg/kg duloxetine or equal volume of 10% dimethylsulfoxide on the 5th week after 6-OHDA microinjection. ((a)–(d)) Systemic application of duloxetine significantly inhibited thermal (a) and mechanical hypersensitivity ((b)–(d)) in the 6-OHDA-lesioned rats (, , and for duloxetine compared to the vehicle control, = 5–7 for each group). ((e)–(h)) Systemic application of sertraline (10 mg/kg, i.p.) did not significantly affect thermal (e) and mechanical hypersensitivity ((f)–(h)) in the 6-OHDA-lesioned rats (, for each group).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)