Synaptic Cell Adhesion Molecules in Alzheimer’s Disease

Figure 3

Synaptic CAMs function as receptors for Aβ. Schematic representation of a synapse showing presynaptic and postsynaptic CAMs, which bind to Aβ. Direct interaction with Aβ has been demonstrated for NCAM2, neuroligin, , and L1 (solid red arrows). Binding of Aβ to integrins and N-cadherins is suggested by indirect observations and remains to be confirmed in a direct binding assay (dashed red arrows).