Brain Responses during the Anticipation of Dyspnea
Psychophysiological interactions during the anticipation period. (a) During the anticipation of severe as compared to mild dyspnea the left anterior insular cortex shows significantly increased coactivation with ACC (, , ; ROI-corrected ) and right insular cortex (, , ; ROI-corrected ). (b) The left parietal operculum shows increased coactivation with ACC (, , ; ROI-corrected ) and right insular cortex (, , ; ROI-corrected ). (c) The left cerebellar cortex shows increased coactivation with the amygdala, bilaterally (, , ; ROI-corrected and , , ; ROI-corrected , resp.). The nonsignificant interactions within the rostral cingulate cortex (b) and primary sensorimotor cortex (c) were outside our ROIs and did not reach whole-brain-corrected significance. All interactions are displayed at a threshold of , corrected for the specific ROI, and superimposed on the group-specific T1-weighted mean image generated by the DARTEL-protocol.
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