Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait

Figure 5

CPP induced by cocaine (1 mg/kg) in HNS and LNS adolescent mice pretreated 6 days before initiation of conditioning with vehicle (HNS, ; LNS, ), 0.1 mg/kg of WIN 55212-2 (HNS, ; LNS, ), or 1 mg/kg of rimonabant (HNS, ; LNS, ). Bars represent time in seconds spent in the drug-paired compartment during preconditioning (white), postconditioning (black), the last extinction session (light grey), and reinstatement (dark grey). Values are mean ± SEM. , difference with respect to the preconditioning session. , difference with respect to the previous extinction session.