Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism

Figure 4

(a) Effect of local intracerebral injection of RU38486 at 5 min prior to initial test on retention of acquired immobility (top) and (b) plasma CORT level (bottom). Behavioural data are expressed as percentage (mean ± the standard error of the mean) of the value observed in rats injected with vehicle. Endocrine data are expressed as micrograms CORT per 100 mL plasma. Open areas represent control injections and closed areas the CORT levels after administration of RU38486. The number of animals is indicated in the figure. The figure comes from de Kloet et al. [17]. as compared to controls. PFN is thalamic parafascular nucleus; PVN is hypothalamic paraventricular nucleus; DG is dentate gyrus. Adapted and reprinted with permission from Karger.

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