Research Article

A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD

Table 1

Overview of included studies, their characteristics, and Hardy-Weinberg equilibrium.

StudySample sourceSample genderTrauma type Diagnostic toolSample size PatientsControlsEthn.Val/ValVal/MetMet/MetHWE

Zhang et al., 2006 [16]HospitalMixedN/ASCID DSM III-R, SADS-L (PTSD section)34696250Cauc.PTSD: 69 
Controls: 166
PTSD: 26
Controls: 74
PTSD: 1
Controls: 10
PTSD:
Controls:

Valente et al., 2011 [28]HospitalN/AUrban viol.CIDI, SCID, CAPS, BAI, BDI, ETI83265767Braz.PTSD: 48
PTSD−: 29
Controls: 555
PTSD: 15
PTSD−: 5
Controls: 164
PTSD: 2 
PTSD−: 0 
Controls: 14
PTSD:
PTSD−:
Controls:

Lee et al., 2006 [30]Health centres; random controlsMixedN/ASCID DSM IV, Korean version268107161KoreanPTSD: 28
Controls: 48
PTSD: 57
Controls: 82
PTSD: 22
Controls: 31
PTSD:
Controls:

Pivac et al., 2012 [22] (add. inf.)HospitalMaleCombatSCID DSM IV, PANSS, CAPS638373265Cauc.PTSD: 235
PTSD−: 173
PTSD: 126
PTSD−: 86
PTSD: 12
PTSD−: 6
PTSD:
PTSD−:

Zhang et al., 2014 [27]US Army Special Ops. N/ACombatPCL for DSM IV, Life Events Checklist46142419MixedPTSD: 20
PTSD−: 294
PTSD: 16
PTSD−: 104
PTSD: 6
PTSD−: 21
PTSD:
PTSD−:

Lyoo et al., 2011 [31]Daegu registry, local comm.MixedSubway disasterCAPS, Structured Clinical Interviews for DSM IV663036South KoreanPTSD: 10
Controls: 14
PTSD: 15
Controls: 18
PTSD: 5
Controls: 4
PTSD:
Controls:

Our studyHospital; RSLMaleCombatCAPS, Semi-structured Clinical Interviews for DSM V257151106Cauc.PTSD: 99
PTSD−: 71
PTSD: 46
PTSD−: 28
PTSD: 6
PTSD−: 7
PTSD:
PTSD−:

Li et al., 2016 [23]High schoolN/ANatural disasterPCL-C (DSM IV)531161370Han Chin.PTSD: 39
PTSD−: 109
PTSD: 80
PTSD−: 190
PTSD: 42
PTSD−: 71
PTSD:
PTSD−:

Dretsch et al., 2016 [29]US ArmyN/ACombatPCL-M22641185MixedPTSD: 28
PTSD−: 129
PTSD: 8
PTSD−: 49
PTSD: 5
PTSD−: 7
PTSD:
PTSD−:

Note. Ethn., ethnicity; HWE, Hardy-Weinberg equilibrium; N/A, not available; Cauc., Caucasian; Braz., Brazilian; Chin., Chinese; viol., violence; PTSD−, trauma exposed but no PTSD diagnosis; controls, no trauma exposure; add. inf., includes additional information; comm., community; RSL, Returned Services League; SCID, Structured Clinical Interview for DSM; DSM, Diagnostic and Statistical Manual for Mental Disorders; SADS-L, schedule for affective disorders and schizophrenia-lifetime version; CIDI, Composite International Diagnostic Interview; CAPS, Clinician-administered PTSD scale; BAI, Beck Anxiety Interview; BDI, Beck Depression Inventory; ETI, Early Trauma Inventory; PANSS, Positive and Negative Syndrome Scale; PCL, Posttraumatic Stress Disorder Checklist.