A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD

Table 6

Results of the overall meta-analysis including all studies and stepwise removal of Zhang et al. (2014) [27] and Dretsch et al. (2016) [29] in a random-effects model.

Analysis	Model	Odds ratio	95% CI		Fail safe
All studies	Val/Val versus Val/Met	0.92	0.57; 1.47	82.87	N/A
	Val/Val versus Met/Met	0.87	0.15; 4.97	96.28	N/A
	Recessive	0.87	0.56; 1.34	89.35	N/A
	Dominant	1.44	0.61; 3.38	86.99	N/A
	Allele	1.20	0.65; 2.20	95.02	1.20
Zhang et al. (2014) [27] removed	Val/Val versus Val/Met	0.97	0.70; 1.36	62.25	N/A
	Val/Val versus Met/Met	1.02	0.19; 5.56	95.51	0.14
	Recessive	0.65	0.39; 1.10	N/A	N/A
	Dominant	1.24	0.60; 2.60	78.30	1.46
	Allele	1.10	0.88; 1.37	55.34	0.60
Zhang et al. (2014) [27] and Dretsch et al. (2016) [29] removed	Val/Val versus Val/Met	0.82	0.70; 0.96	N/A	N/A
	Val/Val versus Met/Met	1.22	0.19; 7.66	95.79	1.10
	Recessive	0.90	0.81;	N/A	N/A
	Dominant	1.07	0.48; 2.39	81.40	0.37
	Allele	1.08	0.85; 1.35	58.51	0.38

Note. Significant findings are in bold; approaching significance.