Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB

Table 1

Overview of NF-B target genes in synaptic plasticity.

Target gene	Location	Effect	Gene description	Reference
Neurotrophic factors
IGF2	Postsynaptic	Direct	Insulin-like growth factor 2	[34]
BDNF	In astrocytes	Direct	Brain-derived neurotrophic factor	[41]
Structural/adhesion/scaffolding proteins
PSD95	Postsynaptic	Indirect	Postsynaptic density compartment (also SAP90); membrane-associated guanylate kinase	[23, 34]
SAP97	Postsynaptic	Indirect	Synapse-associated protein 97; or disks large homolog 1 (DLG1)	[34]
NCAM	Postsynaptic	Direct	Neuronal cell adhesion molecule	[42]
ICAM3	Postsynaptic	Direct	Intercellular adhesion molecule 3	[43]
Slitrk1	Postsynaptic	Direct	SLIT and NTRK-like family member 1	[44]
Tiam1	Postsynaptic	Direct	T-cell lymphoma invasion and metastasis-inducing protein 1	[44]
Receptor and signaling proteins
Calbindin	Postsynaptic	Indirect	Calcium binding protein -D28k and -D9k	[45, 46]
CaMKII	Postsynaptic	Direct	Ca(2+)/calmodulin-dependent protein kinase type II alpha chain	[47]
CREB	Postsynaptic	Indirect	cAMP response element-binding protein	[21]
C/EBP	Postsynaptic	Direct	CCAAT/enhancer-binding protein; transcription factor	[48–50]
Egr-1	Postsynaptic	Direct	Early growth response protein 1; or NGFI-A (nerve growth factor-induced protein A)	[51]
Egr-2	Postsynaptic	Direct	Early growth response protein 2	[52]
Fos	Postsynaptic	c-Rel binding sites identified	Transcription factor	[53, 54]
GAD65	Presynaptic	Indirect	Glutamic acid decarboxylase; function in GABA synthesis	[16]
NMDA1 receptor subunit 1; (Grin1)	Postsynaptic	B binding sites identified	Subunit 1 of N-methyl-D-aspartate glutamate receptor	[55]
NMDA2A receptor subunit 2A (Grin2A)	Postsynaptic	B binding sites identified	Subunit 2A of N-methyl-D-aspartate glutamate receptor	[56]
mGluR2	Postsynaptic	Direct	Metabotropic glutamate receptor 2	[57]
PKAcat	Postsynaptic; (hippocampus)	Direct	Protein kinase A catalytic subunit α	[21]