Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

Figure 1

Ictal discharges (electroencephalographic seizure activity) in APPswePS1dE9 Alzheimer mice. (a and b) Representative 1 min EEG traces recorded from female controls (I) and APPswePS1dE9 mice (II) using a deep, intracerebral CA1 deflection (a) and an epidural surface electrode on the primary motor cortex (M1, b). Note that Alzheimer mice (II) display spike/spike train episodes which are characterized by spiking initiation (1), continuation (2), and termination (3). Reduced EEG amplitude following seizure termination represents postictal depression (4). Electroencephalographic seizure activity is present in both cortical and intrahippocampal recordings. (c and d) Representative 1 min EEG traces from male controls (I) and Alzheimer mice (II) obtained from CA1 (c) and M1 (d) deflections. As for females, spike/spike-wave train episodes are prominent in APPswePS1dE9 animals (time bar, 5 s; voltage bar, 200 μV).

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