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Neural Plasticity
Volume 2016, Article ID 7167358, 16 pages
Research Article

Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

1Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM)), Bonn, Germany
2German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)), Bonn, Germany
3Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Received 21 July 2016; Revised 7 September 2016; Accepted 19 September 2016

Academic Editor: Christian Wozny

Copyright © 2016 Anna Papazoglou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Activity analysis in female controls and APPswePS1dE9 mice. Female animals from both groups were analyzed for motor activity (relative units) for different ages (14, 15, 18, 19 wks) and circadian periods (D1, L1, D2, L2, D1+D2, L1+L2). In females, no changes were observed in motor activity. Black, controls; gray, APPswePS1dE9.

Supplementary Figure 2: Electroencephalographic seizure analysis in controls and APPswePS1dE9. Both M1 (A) and CA1 (B) 48 hrs long-term EEG recordings were analyzed for electroencephalographic seizures using an automated seizure detection tool. Seizure parameters included the number of spike trains as well as the average spike train duration and were averaged for a single dark (D) or light (L) cycle for the various ages (14, 15, 18, 19 wks). Black, controls; gray, APPswePS1dE9.

Supplementary Figure 3: Gender specific frequency analysis in controls and APPswePS1dE9 mice during the active and inactive state. The mean EEG power [%] was calculated FFT based for males and females considering potential circadian rhythmicity (light / dark phase) and also the activity status (active, activity counts > 0; inactive, activity = 0). For CA1 deflections, theta (4-8 Hz), gamma (30-50 Hz) and gamma (50-70 Hz) were quantified. Frequency analysis was performed for all four ages (14, 15, 18, 19 wks). Black, controls; gray, APPswePS1dE9.

  1. Supplementary Material